John Krystal, Chair of the Department of Psychiatry at Yale University, discusses the science behind ketamine and its rapid, powerful effects on treatment‑resistant depression. He explains how ketamine’s action on the brain’s glutamate system and neuroplasticity is reshaping psychiatric care and offering new hope for patients who have not responded to conventional treatments.

This interview was filmed as part of Quiet the Sirens which follows three firefighters confronting PTSD as they pursue healing through an innovative ketamine‑assisted group therapy program, offering an intimate look at trauma, recovery, and the evolving future of mental health care.